| Host: |
Rabbit |
| Applications: |
WB/ELISA/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Ras and Rab interactor 1 (655-704 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RIN1 |
| Gene ID: |
9610 |
| Uniprot ID: |
RIN1_HUMAN |
| Immunogen Region: |
655-704 aa |
| Specificity: |
RIN1 Polyclonal Antibody detects endogenous levels of RIN1 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human RIN1 at the amino acid range 655-704 |
| Post Translational Modifications | Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylation at Ser-351 by PRKD1 induces interaction with 14-3-3 proteins. |
| Function | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. |
| Protein Name | Ras And Rab Interactor 1Ras Inhibitor Jc99Ras Interaction/Interference Protein 1 |
| Database Links | Reactome: R-HSA-8876198 |
| Cellular Localisation | CytoplasmMembraneCytoskeletonSome Amount Is Membrane-Associated |
| Alternative Antibody Names | Anti-Ras And Rab Interactor 1 antibodyAnti-Ras Inhibitor Jc99 antibodyAnti-Ras Interaction/Interference Protein 1 antibodyAnti-RIN1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
