Anti-RIN1 antibody (655-704 aa) (STJ95509)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human RIN1 at the amino acid range 655-704
General Information
| Short Description | Rabbit polyclonal anti-Ras and Rab interactor 1 (655-704 aa) for use in WB, ELISA and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RIN1 |
| Gene ID | 9610 |
| Uniprot ID | RIN1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human RIN1 at the amino acid range 655-704 |
| Immunogen Region | 655-704 aa |
| Specificity | RIN1 Polyclonal Antibody detects endogenous levels of RIN1 protein. |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylation at Ser-351 by PRKD1 induces interaction with 14-3-3 proteins. |
| Function | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. |
| Protein Name | Ras And Rab Interactor 1Ras Inhibitor Jc99Ras Interaction/Interference Protein 1 |
| Database Links | Reactome: R-HSA-8876198 |
| Cellular Localisation | CytoplasmMembraneCytoskeletonSome Amount Is Membrane-Associated |
| Alternative Antibody Names | Anti-Ras And Rab Interactor 1 antibodyAnti-Ras Inhibitor Jc99 antibodyAnti-Ras Interaction/Interference Protein 1 antibodyAnti-RIN1 antibody |
Information sourced from Uniprot.org