• Flow cytometric analysis of Hela cells using Rictor monoclonal antibody (green) and negative control (purple).
  • Immunohistochemistry analysis of paraffin-embedded thyroid gland tissues (left) and human breast carcinoma (right) with DAB staining using Rictor monoclonal antibody.
  • Immunofluorescence analysis of NIH/3T3 cells using Rictor monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
  • Western blot analysis using Rictor monoclonal antibody against HeLa (1) , PANC-1 (2) , MOLT4 (3) , HepG2 (4) and HEK293 (5) cell lysate.

Anti-RICTOR antibody [7B3] (STJ98362)

SKU:
STJ98362

£144.00 - £348.00
Current Stock:
Host: Mouse
Applications: WB/IHC/IF/FC/ELISA
Reactivity: Human/Mouse/Monkey
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Rapamycin-insensitive companion of mTOR is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry and ELISA research applications.
Clonality: Monoclonal
Clone ID: 7B3
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC 1:200-1:1000
IF 1:200-1:1000
FC 1:200-1:400
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RICTOR
Gene ID: 253260
Uniprot ID: RICTR_HUMAN
Specificity: Rictor Monoclonal Antibody detects endogenous levels of Rictor protein.
Immunogen: Purified recombinant fragment of human Rictor expressed in E. Coli.
Function Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
Protein Name Rapamycin-Insensitive Companion Of Mtor
Avo3 Homolog
Havo3
Database Links Reactome: R-HSA-1257604
Reactome: R-HSA-389357
Reactome: R-HSA-5218920
Reactome: R-HSA-5674400
Reactome: R-HSA-6804757
Alternative Antibody Names Anti-Rapamycin-Insensitive Companion Of Mtor antibody
Anti-Avo3 Homolog antibody
Anti-Havo3 antibody
Anti-RICTOR antibody
Anti-KIAA1999 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance