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Anti-Ribonuclease 7 antibody [4C4] (STJA0002900)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenRecombinant human RNase 7 protein produced by CHO-based proprietary suspension cell line. Human Ribonuclease 7
General Information
| Short Description | Mouse monoclonal anti-Ribonuclease 7 for use in ELISA, WB, IHC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/IHC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 4C4 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | Protein G purification |
| Dilution Range | ELISA 0.05 to 0.1 µg/ml; WB 0.5 to 1 µg/ml; IF 0.2 to 20 µg/ml; IHC 2 to 20 µg/ml; Monoclonal antibody optimal dilution has to be established practically for each antigen and assay format |
| Formulation | PBS pH 7.4, with 0.1% sodium azide |
| Storage Instruction | Store at-20 or-70 °C upon receipt. Divide antibody into aliquots prior usage. Avoid multiple freeze-thaw cycles as product degradation may result |
Target Information
| Gene Symbol | RNASE7 |
| Gene ID | 84659 |
| Uniprot ID | RNAS7_HUMAN |
| Immunogen | Recombinant human RNase 7 protein produced by CHO-based proprietary suspension cell line. Human Ribonuclease 7 |
| Specificity | Human Ribonuclease 7 |
Additional Info
| Tissue Specificity | Expressed in collecting ducts in kidney, and in apical uroepithelium in bladder (at protein level). Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary tract and, at a low level, in the gut. Expressed in liver, kidney, skeletal muscle and heart. |
| Function | Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms including uropathogenic E.coli (UPEC), and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium. Causes loss of bacterial membrane integrity. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity. |
| Protein Name | Ribonuclease 7Rnase 7Skin-Derived Antimicrobial Protein 2Sap-2 |
| Database Links | Reactome: R-HSA-6803157 |
| Cellular Localisation | SecretedDetected In Urine |
| Alternative Antibody Names | Anti-Ribonuclease 7 antibodyAnti-Rnase 7 antibodyAnti-Skin-Derived Antimicrobial Protein 2 antibodyAnti-Sap-2 antibodyAnti-RNASE7 antibodyAnti-UNQ2516 antibodyAnti-PRO6006 antibody |
Information sourced from Uniprot.org