| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RhoU (Internal Region) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
RHOU |
| Gene ID: |
58480 |
| Uniprot ID: |
RHOU_HUMAN |
| Immunogen Region: |
Internal Region |
| Specificity: |
Specific for RhoU. |
| Immunogen: |
A synthetic peptide from the internal region of human Rho related GTP binding protein RhoU (CDC42 like GTPase 1, CDC42L1, Ryu GTPase) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 90% identity with rat and |
| Post Translational Modifications | Tyrosine phosphorylated by SRC in response to PTK2B/PYK2 activation. |
| Function | Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. |
| Protein Name | Rho-Related Gtp-Binding Protein RhouCdc42-Like Gtpase 1Gtp-Binding Protein-Like 1Rho Gtpase-Like Protein ArhuRyu GtpaseWnt-1 Responsive Cdc42 Homolog 1Wrch-1 |
| Database Links | Reactome: R-HSA-6785807Reactome: R-HSA-9013420 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideGolgi Apparatus MembraneCell JunctionFocal AdhesionCell ProjectionPodosomeLocalizes To Podosomes In Src-Transformed Cells |
| Alternative Antibody Names | Anti-Rho-Related Gtp-Binding Protein Rhou antibodyAnti-Cdc42-Like Gtpase 1 antibodyAnti-Gtp-Binding Protein-Like 1 antibodyAnti-Rho Gtpase-Like Protein Arhu antibodyAnti-Ryu Gtpase antibodyAnti-Wnt-1 Responsive Cdc42 Homolog 1 antibodyAnti-Wrch-1 antibodyAnti-RHOU antibodyAnti-ARHU antibodyAnti-CDC42L1 antibodyAnti-G28K antibodyAnti-WRCH1 antibodyAnti-SB128 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
