| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RHOU (40-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RHOU |
| Gene ID: |
58480 |
| Uniprot ID: |
RHOU_HUMAN |
| Immunogen Region: |
40-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 40-100 of human RHOU (NP_067028.1). |
| Immunogen Sequence: |
GRAGGAEGRGVKCVLVGDGA VGKTSLVVSYTTNGYPTEYI PTAFDNFSAVVSVDGRPVRL Q |
| Tissue Specificity | Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta. |
| Post Translational Modifications | Tyrosine phosphorylated by SRC in response to PTK2B/PYK2 activation. |
| Function | Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. |
| Protein Name | Rho-Related Gtp-Binding Protein RhouCdc42-Like Gtpase 1Gtp-Binding Protein-Like 1Rho Gtpase-Like Protein ArhuRyu GtpaseWnt-1 Responsive Cdc42 Homolog 1Wrch-1 |
| Database Links | Reactome: R-HSA-6785807Reactome: R-HSA-9013420 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideGolgi Apparatus MembraneCell JunctionFocal AdhesionCell ProjectionPodosomeLocalizes To Podosomes In Src-Transformed Cells |
| Alternative Antibody Names | Anti-Rho-Related Gtp-Binding Protein Rhou antibodyAnti-Cdc42-Like Gtpase 1 antibodyAnti-Gtp-Binding Protein-Like 1 antibodyAnti-Rho Gtpase-Like Protein Arhu antibodyAnti-Ryu Gtpase antibodyAnti-Wnt-1 Responsive Cdc42 Homolog 1 antibodyAnti-Wrch-1 antibodyAnti-RHOU antibodyAnti-ARHU antibodyAnti-CDC42L1 antibodyAnti-G28K antibodyAnti-WRCH1 antibodyAnti-SB128 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
