Anti-RHO/Rhodopsin antibody [K42-41L] (STJA0019677)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Rhodopsin antibody for use in Blocking, ELISA and ICC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | Blocking/ELISA/ICC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | K42-41L |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | RHO |
| Gene ID | 6010 |
| Uniprot ID | OPSD_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region. After activation by light, phosphorylated by GRK1 (in vitro). Contains one covalently linked retinal chromophore. Upon light absorption, the covalently bound 11-cis-retinal is converted to all-trans-retinal. After hydrolysis of the Schiff base and release of the covalently bound all-trans-retinal, active rhodopsin is regenerated by binding of a fresh molecule of 11-cis-retinal. |
| Function | Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. |
| Protein Name | RhodopsinOpsin-2 |
| Database Links | Reactome: R-HSA-2453902Reactome: R-HSA-2485179Reactome: R-HSA-2514859Reactome: R-HSA-418594Reactome: R-HSA-419771Reactome: R-HSA-5620916 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCell ProjectionCiliumPhotoreceptor Outer SegmentSynthesized In The Inner Segment (Is) Of Rod Photoreceptor Cells Before Vectorial Transport To Disk Membranes In The Rod Outer Segment (Os) Photosensory Cilia |
| Alternative Antibody Names | Anti-Rhodopsin antibodyAnti-Opsin-2 antibodyAnti-RHO antibodyAnti-OPN2 antibody |
Information sourced from Uniprot.org