| Host: |
Rabbit |
| Applications: |
WB/ELISA/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Regulator of G-protein signaling 7 (155-204 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RGS7 |
| Gene ID: |
6000 |
| Uniprot ID: |
RGS7_HUMAN |
| Immunogen Region: |
155-204 aa |
| Specificity: |
RGS7 Polyclonal Antibody detects endogenous levels of RGS7 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human RGS7 at the amino acid range 155-204 |
| Function | GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades. The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form. May play a role in synaptic vesicle exocytosis (Probable). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling. |
| Protein Name | Regulator Of G-Protein Signaling 7Rgs7 |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-6814122 |
| Cellular Localisation | CytoplasmCytosolCell MembraneMembranePeripheral Membrane ProteinCytoplasmic SideInteraction With Pkd1 Promotes Location At The Cell MembraneInteraction With Rgs7bp Promotes Location At The Cell Membrane |
| Alternative Antibody Names | Anti-Regulator Of G-Protein Signaling 7 antibodyAnti-Rgs7 antibodyAnti-RGS7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
