Anti-RGS2 antibody (STJA0004385)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein of human RGS2
General Information
| Short Description | Rabbit polyclonal anti-Regulator Of G-Protein Signaling 2 for use in IHC and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.1 mg/mL |
| Purification | Affinity purification |
| Dilution Range | IHC 1:50-1:200 |
| Formulation | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | RGS2 |
| Gene ID | 5997 |
| Uniprot ID | RGS2_HUMAN |
| Immunogen | Recombinant protein of human RGS2 |
Additional Info
| Tissue Specificity | Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL). |
| Post Translational Modifications | Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity. |
| Function | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. It is involved in the negative regulation of the angiotensin-activated signaling pathway. Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein. |
| Protein Name | Regulator Of G-Protein Signaling 2Rgs2Cell Growth-Inhibiting Gene 31 ProteinG0/G1 Switch Regulatory Protein 8 |
| Database Links | Reactome: R-HSA-416476 |
| Cellular Localisation | Isoform 1: Cell MembraneCytoplasmNucleusNucleolusIsoform 2: Cell MembraneIsoform 3: Cell MembraneIsoform 4: Cell MembraneMitochondrion |
| Alternative Antibody Names | Anti-Regulator Of G-Protein Signaling 2 antibodyAnti-Rgs2 antibodyAnti-Cell Growth-Inhibiting Gene 31 Protein antibodyAnti-G0/G1 Switch Regulatory Protein 8 antibodyAnti-RGS2 antibodyAnti-G0S8 antibodyAnti-GIG31 antibody |
Information sourced from Uniprot.org