Anti-REXO2 antibody (STJA0009156)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human REXO2
General Information
| Short Description | Rabbit polyclonal anti-Oligoribonuclease, mitochondrial for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | REXO2 |
| Gene ID | 25996 |
| Uniprot ID | ORN_HUMAN |
| Immunogen | Synthesized peptide derived from human REXO2 |
| Specificity | This antibody detects endogenous levels of REXO2 at Human, Mouse, Rat |
Additional Info
| Function | 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. Binds and degrades longer oligonucleotides with a lower affinity. Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing. Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome. Essential for embryonic development. Isoform 3: 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. |
| Protein Name | Oligoribonuclease - MitochondrialRna Exonuclease 2 HomologSmall Fragment Nuclease |
| Database Links | Reactome: R-HSA-9836573 |
| Cellular Localisation | Mitochondrion Intermembrane SpaceMitochondrion MatrixMitochondrionCytoplasmNucleusIsoform 3: Cytoplasm |
| Alternative Antibody Names | Anti-Oligoribonuclease - Mitochondrial antibodyAnti-Rna Exonuclease 2 Homolog antibodyAnti-Small Fragment Nuclease antibodyAnti-REXO2 antibodyAnti-SFN antibodyAnti-SMFN antibodyAnti-CGI-114 antibody |
Information sourced from Uniprot.org