Anti-REG3G antibody (STJA0004514)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein of human REG3G
General Information
| Short Description | Rabbit polyclonal anti-Regenerating Islet-Derived Protein 3-Gamma for use in WB, IHC and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.8 mg/mL |
| Purification | Affinity purification |
| Dilution Range | WB 1:500-1:2000, IHC 1:100-1:300 |
| Formulation | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | REG3G |
| Gene ID | 130120 |
| Uniprot ID | REG3G_HUMAN |
| Immunogen | Recombinant protein of human REG3G |
Additional Info
| Tissue Specificity | Predominantly expressed in pancreas, where it may be restricted to exocrine pancreas. Moderate expression levels in testis and weak in heart, kidney and placenta. |
| Post Translational Modifications | Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity. |
| Function | Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Is secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury. In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF. Induced by IL22 in lung epithelial cells, inhibits cytokine production and regulates allergic airway inflammation. Induced in small intestine by inulin-enriched diet and Lactobacillus gasseri enriched microbiome, plays a role in the improvement of gut barrier function, the regulation of energy balance and glucose levels. Modulates microbiota composition in duodenal contents. Produced by nociceptor in response to endotoxins, prevents endotoxic death by targeting kynurenine pathway in microglia. Regenerating islet-derived protein 3-gamma 16.5 kDa form: Has bacteriostatic activity. Regenerating islet-derived protein 3-gamma 15 kDa form: Has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. |
| Protein Name | Regenerating Islet-Derived Protein 3-GammaReg-3-GammaPancreatitis-Associated Protein 1bPap-1bPancreatitis-Associated Protein IbPap IbRegenerating Islet-Derived Protein Iii-GammaReg IiiReg Iii-Gamma Cleaved Into - Regenerating Islet-Derived Protein 3-Gamma 16.5 Kda Form - Regenerating Islet-Derived Protein 3-Gamma 15 Kda Form |
| Database Links | Reactome: R-HSA-6803157 |
| Cellular Localisation | SecretedCytoplasm |
| Alternative Antibody Names | Anti-Regenerating Islet-Derived Protein 3-Gamma antibodyAnti-Reg-3-Gamma antibodyAnti-Pancreatitis-Associated Protein 1b antibodyAnti-Pap-1b antibodyAnti-Pancreatitis-Associated Protein Ib antibodyAnti-Pap Ib antibodyAnti-Regenerating Islet-Derived Protein Iii-Gamma antibodyAnti-Reg Iii antibodyAnti-Reg Iii-Gamma Cleaved Into - Regenerating Islet-Derived Protein 3-Gamma 16.5 Kda Form - Regenerating Islet-Derived Protein 3-Gamma 15 Kda Form antibodyAnti-REG3G antibodyAnti-PAP1B antibodyAnti-UNQ429 antibodyAnti-PRO162 antibody |
Information sourced from Uniprot.org