| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-REG3A (27-175) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
REG3A |
| Gene ID: |
5068 |
| Uniprot ID: |
REG3A_HUMAN |
| Immunogen Region: |
27-175 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 27-175 of human REG3A (NP_002571.1). |
| Immunogen Sequence: |
EEPQRELPSARIRCPKGSKA YGSHCYALFLSPKSWTDADL ACQKRPSGNLVSVLSGAEGS FVSSLVKSIGNSYSYVWIGL HDPTQGTEPNGEGWEWSSSD VMNYFAWERNPSTISSPGHC ASLSRSTAFLRWKDYNCNVR LPYVCKFTD |
| Tissue Specificity | Expressed by keratinocytes. Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis. |
| Post Translational Modifications | Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity. |
| Function | Regenerating islet-derived protein 3-alpha 15 kDa form: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Binds membrane phospholipids and kills bacteria by forming a hexameric membrane-permeabilizing oligomeric pore. Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF. In pancreas, is able to permealize beta-cells membrane and stimulate their proliferation. Regenerating islet-derived protein 3-alpha 16.5 kDa form: Has bacteriostatic activity. |
| Protein Name | Regenerating Islet-Derived Protein 3-AlphaReg-3-AlphaHepatointestinal Pancreatic ProteinHip/PapHuman Proislet PeptideHipPancreatitis-Associated Protein 1Regenerating Islet-Derived Protein Iii-AlphaReg Iii-Alpha Cleaved Into - Regenerating Islet-Derived Protein 3-Alpha 16.5 Kda Form - Regenerating Islet-Derived Protein 3-Alpha 15 Kda Form |
| Database Links | Reactome: R-HSA-6803157 |
| Cellular Localisation | SecretedFound In The Apical Region Of Pancreatic Acinar Cells |
| Alternative Antibody Names | Anti-Regenerating Islet-Derived Protein 3-Alpha antibodyAnti-Reg-3-Alpha antibodyAnti-Hepatointestinal Pancreatic Protein antibodyAnti-Hip/Pap antibodyAnti-Human Proislet Peptide antibodyAnti-Hip antibodyAnti-Pancreatitis-Associated Protein 1 antibodyAnti-Regenerating Islet-Derived Protein Iii-Alpha antibodyAnti-Reg Iii-Alpha Cleaved Into - Regenerating Islet-Derived Protein 3-Alpha 16.5 Kda Form - Regenerating Islet-Derived Protein 3-Alpha 15 Kda Form antibodyAnti-REG3A antibodyAnti-HIP antibodyAnti-PAP antibodyAnti-PAP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
