Anti-Recombinant-WDR1 antibody [RM1F01] (STJA0023094)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Wd Repeat-Containing Protein 1 for use in IF, IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1F01 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IF: 1:50-1:200 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | WDR1 |
| Gene ID | 9948 |
| Uniprot ID | WDR1_HUMAN |
Additional Info
| Function | Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing. Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions. Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance. Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP.the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension. Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt. |
| Protein Name | Wd Repeat-Containing Protein 1Actin-Interacting Protein 1Aip1Nori-1 |
| Database Links | Reactome: R-HSA-114608 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionPodosomeCell Junction |
| Alternative Antibody Names | Anti-Wd Repeat-Containing Protein 1 antibodyAnti-Actin-Interacting Protein 1 antibodyAnti-Aip1 antibodyAnti-Nori-1 antibodyAnti-WDR1 antibody |
Information sourced from Uniprot.org