Anti-Recombinant-VCL/Vinculin antibody [RM1A75] (STJA0026746)

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STJA0026746
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Host: Rabbit
Applications: IF/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Vinculin is suitable for use in Immunofluorescence, Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM1A75
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IF: 1:50-1:200, IP: 1:20-1:50, WB: 1:1000-1:5000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: VCL
Gene ID: 7414
Uniprot ID: VINC_HUMAN
Post Translational Modifications Phosphorylated.on serines, threonines and tyrosines. Phosphorylation on Tyr-1133 in activated platelets affects head-tail interactions and cell spreading but has no effect on actin binding nor on localization to focal adhesion plaques. Acetylated.mainly by myristic acid but also by a small amount of palmitic acid.
Function Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
Protein Name Vinculin
Metavinculin
Mv
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-445355
Reactome: R-HSA-5674135
Reactome: R-HSA-6798695
Reactome: R-HSA-6802946
Reactome: R-HSA-6802948
Reactome: R-HSA-6802952
Reactome: R-HSA-6802955
Reactome: R-HSA-9649948
Reactome: R-HSA-9656223
Reactome: R-HSA-9725370
Cellular Localisation Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cell Junction
Adherens Junction
Focal Adhesion
Cytoplasm
Cytoskeleton
Sarcolemma
Cell Projection
Podosome
Recruitment To Cell-Cell Junctions Occurs In A Myosin Ii-Dependent Manner
Interaction With Ctnnb1 Is Necessary For Its Localization To The Cell-Cell Junctions
Alternative Antibody Names Anti-Vinculin antibody
Anti-Metavinculin antibody
Anti-Mv antibody
Anti-VCL antibody

Information sourced from Uniprot.org