Anti-Recombinant-VAMP1 antibody [RM1S49] (STJA0024231)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Vesicle-Associated Membrane Protein 1 for use in IF, IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1S49 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IF: 1:50-1:200 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | VAMP1 |
| Gene ID | 6843 |
| Uniprot ID | VAMP1_HUMAN |
Additional Info
| Post Translational Modifications | (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which probably hydrolyzes the 78-Gln-|-Phe-79 bond and inhibits neurotransmitter release. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which probably hydrolyzes the 61-Arg-|-Leu-62 bond and inhibits neurotransmitter release. BoNT/D has low catalytic activity on this protein due to its sequence. Note that humans are not known to be infected by C.botulinum type D. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which probably hydrolyzes the 60-Gln-|-Lys-61 bond and inhibits neurotransmitter release. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type X (BoNT/X) which probably hydrolyzes the 68-Arg-|-Ala-69 bond and inhibits neurotransmitter release. It remains unknown whether BoNT/X is ever produced, or what organisms it targets. |
| Function | Involved in the targeting and/or fusion of transport vesicles to their target membrane. |
| Protein Name | Vesicle-Associated Membrane Protein 1Vamp-1Synaptobrevin-1 |
| Database Links | Reactome: R-HSA-5250955Reactome: R-HSA-5250981Reactome: R-HSA-5250989 |
| Cellular Localisation | Isoform 1: Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneSingle-Pass Type Iv Membrane ProteinSynapseSynaptosomeIsoform 2: Cytoplasmic Vesicle MembraneIsoform 3: Mitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Vesicle-Associated Membrane Protein 1 antibodyAnti-Vamp-1 antibodyAnti-Synaptobrevin-1 antibodyAnti-VAMP1 antibodyAnti-SYB1 antibody |
Information sourced from Uniprot.org