Anti-Recombinant-UBA3 antibody [RM2RM80] (STJA0026539)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Nedd8-Activating Enzyme E1 Catalytic Subunit for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2RM80 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | UBA3 |
| Gene ID | 9039 |
| Uniprot ID | UBA3_HUMAN |
Additional Info
| Function | Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. |
| Protein Name | Nedd8-Activating Enzyme E1 Catalytic SubunitNedd8-Activating Enzyme E1cUbiquitin-Activating Enzyme E1cUbiquitin-Like Modifier-Activating Enzyme 3Ubiquitin-Activating Enzyme 3 |
| Database Links | Reactome: R-HSA-5607761Reactome: R-HSA-5676590Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Nedd8-Activating Enzyme E1 Catalytic Subunit antibodyAnti-Nedd8-Activating Enzyme E1c antibodyAnti-Ubiquitin-Activating Enzyme E1c antibodyAnti-Ubiquitin-Like Modifier-Activating Enzyme 3 antibodyAnti-Ubiquitin-Activating Enzyme 3 antibodyAnti-UBA3 antibodyAnti-UBE1C antibody |
Information sourced from Uniprot.org