Anti-Recombinant-UAP1 antibody [RM2G83] (STJA0025651)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Udp-N-Acetylhexosamine Pyrophosphorylase for use in FC, IF, IHC, IP and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IF/IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2G83 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | UAP1 |
| Gene ID | 6675 |
| Uniprot ID | UAP1_HUMAN |
Additional Info
| Function | Catalyzes the last step in biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) by converting UTP and glucosamine 1-phosphate (GlcNAc-1-P) to the sugar nucleotide. Also converts UTP and galactosamine 1-phosphate (GalNAc-1-P) into uridine diphosphate-N-acetylgalactosamine (UDP-GalNAc). In addition to its role in metabolism, acts as a regulator of innate immunity in response to virus infection by mediating pyrophosphorylation of IRF3: catalyzes pyrophosphorylation of IRF3 phosphorylated at 'Ser-386' by TBK1, promoting IRF3 dimerization and activation, leading to type I interferon responses. Isoform AGX1: Isoform AGX1 has 2 to 3 times higher activity towards galactosamine 1-phosphate (GalNAc-1-P). Isoform AGX1: Isoform AGX2 has 8 times more activity towards glucosamine 1-phosphate (GlcNAc-1-P). |
| Protein Name | Udp-N-Acetylhexosamine PyrophosphorylaseAntigen XAgxProtein-Pyrophosphorylation EnzymeSperm-Associated Antigen 2Udp-N-Acetylgalactosamine PyrophosphorylaseUdp-N-Acetylglucosamine Pyrophosphorylase |
| Database Links | Reactome: R-HSA-446210 |
| Cellular Localisation | CytoplasmCytosolIn SpermatozoaLocalized To The Principal Piece Of The TailThe Neck Region Of The Head And To A Lesser ExtentThe Midpiece Of The Tail |
| Alternative Antibody Names | Anti-Udp-N-Acetylhexosamine Pyrophosphorylase antibodyAnti-Antigen X antibodyAnti-Agx antibodyAnti-Protein-Pyrophosphorylation Enzyme antibodyAnti-Sperm-Associated Antigen 2 antibodyAnti-Udp-N-Acetylgalactosamine Pyrophosphorylase antibodyAnti-Udp-N-Acetylglucosamine Pyrophosphorylase antibodyAnti-UAP1 antibodyAnti-SPAG2 antibody |
Information sourced from Uniprot.org