Anti-Recombinant-U2AF2 antibody [RM1T06] (STJA0024287)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Splicing Factor U2af 65 Kda Subunit for use in IF, IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1T06 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IF: 1:50-1:200 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | U2AF2 |
| Gene ID | 11338 |
| Uniprot ID | U2AF2_HUMAN |
Additional Info
| Function | Plays a role in pre-mRNA splicing and 3'-end processing. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals. |
| Protein Name | Splicing Factor U2af 65 Kda SubunitU2 Auxiliary Factor 65 Kda SubunitHu2af(65Hu2af65U2 Snrnp Auxiliary Factor Large Subunit |
| Database Links | Reactome: R-HSA-159236Reactome: R-HSA-72163Reactome: R-HSA-72187Reactome: R-HSA-73856Reactome: R-HSA-9629569 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Splicing Factor U2af 65 Kda Subunit antibodyAnti-U2 Auxiliary Factor 65 Kda Subunit antibodyAnti-Hu2af(65 antibodyAnti-Hu2af65 antibodyAnti-U2 Snrnp Auxiliary Factor Large Subunit antibodyAnti-U2AF2 antibodyAnti-U2AF65 antibody |
Information sourced from Uniprot.org