Anti-Recombinant-TSG101 antibody [SM0529] (STJA0010529)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenKLH conjugated Synthetic peptide corresponding to Human TSG101
General Information
| Short Description | Mouse monoclonal anti-Recombinant-TSG101 for use in WB in Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Mouse |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SM0529 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB (M, R) 1:500-1:1000 |
| Formulation | PBS with 0.15% ProClin300, 100 Mu g/mL BSA and 50% glycerol. |
| Storage Instruction | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
Target Information
| Gene Symbol | Tsg101 |
| Gene ID | 22088 |
| Uniprot ID | TS101_MOUSE |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Human TSG101 |
Additional Info
| Post Translational Modifications | Monoubiquitinated at multiple sites by LRSAM1 and by MGRN1. Ubiquitination inactivates it, possibly by regulating its shuttling between an active membrane-bound protein and an inactive soluble form. Ubiquitination by MGRN1 requires the presence of UBE2D1. |
| Function | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis.the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan. It may also play a role in the extracellular release of microvesicles that differ from the exosomes. |
| Protein Name | Tumor Susceptibility Gene 101 ProteinEscrt-I Complex Subunit Tsg101 |
| Database Links | Reactome: R-MMU-917729 |
| Cellular Localisation | CytoplasmEarly Endosome MembranePeripheral Membrane ProteinCytoplasmic SideLate Endosome MembraneCytoskeletonMicrotubule Organizing CenterCentrosomeMidbodyMidbody RingNucleusMainly CytoplasmicMembrane-Associated When Active And Soluble When InactiveNuclear Localization Is Cell Cycle-DependentInteraction With Cep55 Is Required For Localization To The Midbody During Cytokinesis |
| Alternative Antibody Names | Anti-Tumor Susceptibility Gene 101 Protein antibodyAnti-Escrt-I Complex Subunit Tsg101 antibodyAnti-Tsg101 antibody |
Information sourced from Uniprot.org