Anti-Recombinant-SOCS2 antibody [RM1D13] (STJA0022908)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Suppressor Of Cytokine Signaling 2 for use in IP and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IP/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1D13 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IP: 1:20 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | SOCS2 |
| Gene ID | 8835 |
| Uniprot ID | SOCS2_HUMAN |
Additional Info
| Post Translational Modifications | Ubiquitinated.mediated by AREL1 and leading to its subsequent proteasomal degradation. Ubiquitination is dependent on its phosphorylation at Ser-52, by PKC. Ubiquitination is stimulated by LPS. Phosphorylation at Ser-52 by PKC facilitates its ubiquitination and proteasomal degradation. |
| Function | Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as EPOR and GHR. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR, following GHR phosphorylation by JAK2. The ECS(SOCS2) also catalyzes ubiquitination and degradation of JAK2-phosphorylated EPOR. |
| Protein Name | Suppressor Of Cytokine Signaling 2Socs-2Cytokine-Inducible Sh2 Protein 2Cis-2Stat-Induced Stat Inhibitor 2Ssi-2 |
| Database Links | Reactome: R-HSA-1266695Reactome: R-HSA-8951664Reactome: R-HSA-9706369Reactome: R-HSA-982772 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Suppressor Of Cytokine Signaling 2 antibodyAnti-Socs-2 antibodyAnti-Cytokine-Inducible Sh2 Protein 2 antibodyAnti-Cis-2 antibodyAnti-Stat-Induced Stat Inhibitor 2 antibodyAnti-Ssi-2 antibodyAnti-SOCS2 antibodyAnti-CIS2 antibodyAnti-SSI2 antibodyAnti-STATI2 antibody |
Information sourced from Uniprot.org