Anti-Recombinant-SMC4 antibody [RM2Q23] (STJA0026383)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Structural Maintenance Of Chromosomes Protein 4 for use in FC, IF and WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IF/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2Q23 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | FCM: 1:20-1:100, IF: 1:50-1:200, WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | SMC4 |
| Gene ID | 10051 |
| Uniprot ID | SMC4_HUMAN |
Additional Info
| Function | Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. |
| Protein Name | Structural Maintenance Of Chromosomes Protein 4Smc Protein 4Smc-4Chromosome-Associated Polypeptide CHcap-CXcap-C Homolog |
| Database Links | Reactome: R-HSA-2299718Reactome: R-HSA-2514853 |
| Cellular Localisation | NucleusCytoplasmChromosomeIn Interphase CellsThe Majority Of The Condensin Complex Is Found In The CytoplasmWhile A Minority Of The Complex Is Associated With ChromatinA Subpopulation Of The Complex However Remains Associated With Chromosome Foci In Interphase CellsDuring MitosisMost Of The Condensin Complex Is Associated With The ChromatinAt The Onset Of ProphaseThe Regulatory Subunits Of The Complex Are Phosphorylated By Cdc2Leading To Condensin's Association With Chromosome Arms And To Chromosome CondensationDissociation From Chromosomes Is Observed In Late Telophase |
| Alternative Antibody Names | Anti-Structural Maintenance Of Chromosomes Protein 4 antibodyAnti-Smc Protein 4 antibodyAnti-Smc-4 antibodyAnti-Chromosome-Associated Polypeptide C antibodyAnti-Hcap-C antibodyAnti-Xcap-C Homolog antibodyAnti-SMC4 antibodyAnti-CAPC antibodyAnti-SMC4L1 antibody |
Information sourced from Uniprot.org