Anti-Recombinant-RTN4RL1 antibody [RM2S09] (STJA0026567)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Reticulon-4 Receptor-Like 1 for use in IF, IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2S09 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | RTN4RL1 |
| Gene ID | 146760 |
| Uniprot ID | R4RL1_HUMAN |
Additional Info
| Function | Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis.protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. |
| Protein Name | Reticulon-4 Receptor-Like 1Nogo Receptor-Like 2Nogo-66 Receptor Homolog 2Nogo-66 Receptor-Related Protein 3Ngr3 |
| Database Links | Reactome: R-HSA-163125 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane RaftPerikaryonCell ProjectionLocalized To The Surface Of NeuronsIncluding Axons |
| Alternative Antibody Names | Anti-Reticulon-4 Receptor-Like 1 antibodyAnti-Nogo Receptor-Like 2 antibodyAnti-Nogo-66 Receptor Homolog 2 antibodyAnti-Nogo-66 Receptor-Related Protein 3 antibodyAnti-Ngr3 antibodyAnti-RTN4RL1 antibodyAnti-NGRH2 antibodyAnti-NGRL2 antibody |
Information sourced from Uniprot.org