Anti-Recombinant-RCOR1 antibody [RM2M55] (STJA0026118)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Rest Corepressor 1 for use in IF, IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2M55 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | RCOR1 |
| Gene ID | 23186 |
| Uniprot ID | RCOR1_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylated by HSV-1 protein kinases in case of infection. |
| Function | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. |
| Protein Name | Rest Corepressor 1Protein Corest |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-8943724Reactome: R-HSA-9679191Reactome: R-HSA-983231 |
| Cellular Localisation | NucleusUpon Infection By Hsv-1It Is Partially Translocated Into The Cytoplasm In An Hsv-1-Dependent Manner |
| Alternative Antibody Names | Anti-Rest Corepressor 1 antibodyAnti-Protein Corest antibodyAnti-RCOR1 antibodyAnti-KIAA0071 antibodyAnti-RCOR antibody |
Information sourced from Uniprot.org