Anti-Recombinant-RCC1 antibody [RM1Q94] (STJA0024078)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Regulator Of Chromosome Condensation for use in IF, IP and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/IP/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1Q94 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IF: 1:50-1:200 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | RCC1 |
| Gene ID | 1104 |
| Uniprot ID | RCC1_HUMAN |
Additional Info
| Function | Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. |
| Protein Name | Regulator Of Chromosome CondensationCell Cycle Regulatory ProteinChromosome Condensation Protein 1 |
| Database Links | Reactome: R-HSA-165054Reactome: R-HSA-180746Reactome: R-HSA-9615933 |
| Cellular Localisation | NucleusChromosomeCytoplasmPredominantly Nuclear In Interphase CellsBinds To Mitotic Chromosomes |
| Alternative Antibody Names | Anti-Regulator Of Chromosome Condensation antibodyAnti-Cell Cycle Regulatory Protein antibodyAnti-Chromosome Condensation Protein 1 antibodyAnti-RCC1 antibodyAnti-CHC1 antibody |
Information sourced from Uniprot.org