Anti-Recombinant-PNKP antibody [RM2RM94] (STJA0026553)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Bifunctional Polynucleotide Phosphatase/Kinase for use in IF, IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2RM94 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | PNKP |
| Gene ID | 11284 |
| Uniprot ID | PNKP_HUMAN |
Additional Info
| Function | Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. |
| Protein Name | Bifunctional Polynucleotide Phosphatase/KinaseDna 5'-Kinase/3'-PhosphatasePolynucleotide Kinase-3'-Phosphatase Includes - Polynucleotide 3'-Phosphatase2'(3'-Polynucleotidase - Polynucleotide 5'-Hydroxyl-Kinase |
| Database Links | Reactome: R-HSA-5649702 |
| Cellular Localisation | NucleusChromosomeLocalizes To Site Of Double-Strand Breaks |
| Alternative Antibody Names | Anti-Bifunctional Polynucleotide Phosphatase/Kinase antibodyAnti-Dna 5'-Kinase/3'-Phosphatase antibodyAnti-Polynucleotide Kinase-3'-Phosphatase Includes - Polynucleotide 3'-Phosphatase antibodyAnti-2'(3'-Polynucleotidase - Polynucleotide 5'-Hydroxyl-Kinase antibodyAnti-PNKP antibody |
Information sourced from Uniprot.org