Anti-Recombinant-PMAIP1 antibody [RM2F02] (STJA0025471)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Phorbol-12-Myristate-13-Acetate-Induced Protein 1 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2F02 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | WB: 1:500-1:1000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | PMAIP1 |
| Gene ID | 5366 |
| Uniprot ID | APR_HUMAN |
Additional Info
| Function | Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. |
| Protein Name | Phorbol-12-Myristate-13-Acetate-Induced Protein 1Pma-Induced Protein 1Immediate-Early-Response Protein AprProtein Noxa |
| Database Links | Reactome: R-HSA-111448Reactome: R-HSA-111453Reactome: R-HSA-6803204 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Phorbol-12-Myristate-13-Acetate-Induced Protein 1 antibodyAnti-Pma-Induced Protein 1 antibodyAnti-Immediate-Early-Response Protein Apr antibodyAnti-Protein Noxa antibodyAnti-PMAIP1 antibodyAnti-NOXA antibody |
Information sourced from Uniprot.org