Anti-Recombinant-Phospho-CTNND1-Ser268 antibody [RM1E81] (STJA0023075)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Phospho-Catenin Delta-1-Ser268 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1E81 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | WB: 1:500-1:1000 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | CTNND1 |
| Gene ID | 1500 |
| Uniprot ID | CTND1_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK5. Dephosphorylated by PTPRJ. |
| Function | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. |
| Protein Name | Catenin Delta-1Cadherin-Associated Src SubstrateCasP120 CateninP120(CtnP120(Cas |
| Database Links | Reactome: R-HSA-418990Reactome: R-HSA-5218920Reactome: R-HSA-8876493Reactome: R-HSA-9762292Reactome: R-HSA-9764302Reactome: R-HSA-9833576 |
| Cellular Localisation | Cell JunctionAdherens JunctionCytoplasmNucleusCell MembraneInteraction With Glis2 Promotes Nuclear TranslocationDetected At Cell-Cell ContactsNanos1 Induces Its Translocation From Sites Of Cell-Cell Contact To The CytoplasmCdh1 Enhances Cell Membrane LocalizationLocalizes To Cell-Cell Contacts As Keratinocyte Differentiation ProgressesIsoform 1a: NucleusIsoform 2a: NucleusIsoform 3a: NucleusIsoform 4a: CytoplasmIsoform 1ab: Cytoplasm |
| Alternative Antibody Names | Anti-Catenin Delta-1 antibodyAnti-Cadherin-Associated Src Substrate antibodyAnti-Cas antibodyAnti-P120 Catenin antibodyAnti-P120(Ctn antibodyAnti-P120(Cas antibodyAnti-CTNND1 antibodyAnti-KIAA0384 antibody |
Information sourced from Uniprot.org