Anti-Recombinant-Phospho-CBL-Ser669 antibody [RM1S13] (STJA0024195)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Phospho-E3 Ubiquitin-Protein Ligase Cbl-Ser669 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1S13 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | WB: 1:500-1:1000 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | CBL |
| Gene ID | 867 |
| Uniprot ID | CBL_HUMAN |
Additional Info
| Function | E3 ubiquitin-protein ligase that acts as a negative regulator of many signaling pathways by mediating ubiquitination of cell surface receptors. Accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and mediates their ubiquitination to terminate signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Ubiquitinates EGFR and SPRY2. Ubiquitinates NECTIN1 following association between NECTIN1 and herpes simplex virus 1/HHV-1 envelope glycoprotein D, leading to NECTIN1 removal from cell surface. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA. |
| Protein Name | E3 Ubiquitin-Protein Ligase CblCasitas B-Lineage Lymphoma Proto-OncogeneProto-Oncogene C-CblRing Finger Protein 55Ring-Type E3 Ubiquitin Transferase CblSignal Transduction Protein Cbl |
| Database Links | Reactome: R-HSA-1059683Reactome: R-HSA-1236382Reactome: R-HSA-1295596Reactome: R-HSA-1433559Reactome: R-HSA-182971Reactome: R-HSA-2173789Reactome: R-HSA-5637810Reactome: R-HSA-5654726Reactome: R-HSA-5654727Reactome: R-HSA-5654732Reactome: R-HSA-5654733Reactome: R-HSA-6807004Reactome: R-HSA-8849469Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8875360Reactome: R-HSA-912631Reactome: R-HSA-9680350Reactome: R-HSA-9706369Reactome: R-HSA-9706377 |
| Cellular Localisation | CytoplasmCell MembraneCell ProjectionCiliumGolgi ApparatusColocalizes With Fgfr2 In Lipid Rafts At The Cell Membrane |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Cbl antibodyAnti-Casitas B-Lineage Lymphoma Proto-Oncogene antibodyAnti-Proto-Oncogene C-Cbl antibodyAnti-Ring Finger Protein 55 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Cbl antibodyAnti-Signal Transduction Protein Cbl antibodyAnti-CBL antibodyAnti-CBL2 antibodyAnti-RNF55 antibody |
Information sourced from Uniprot.org