Anti-Recombinant-Phospho-ACACA-Ser79 antibody [RM2D74] (STJA0025345)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Phospho-Acetyl-Coa Carboxylase 1-Ser79 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2D74 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | WB: 1:500-1:1000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | ACACA |
| Gene ID | 31 |
| Uniprot ID | ACACA_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylation on Ser-1263 is required for interaction with BRCA1. Phosphorylation at Ser-80 by AMPK inactivates enzyme activity. The biotin cofactor is covalently attached to the central biotinyl-binding domain and is required for the catalytic activity. |
| Function | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. |
| Protein Name | Acetyl-Coa Carboxylase 1Acc1Acetyl-Coenzyme A Carboxylase AlphaAcc-Alpha |
| Database Links | Reactome: R-HSA-163765Reactome: R-HSA-196780Reactome: R-HSA-200425Reactome: R-HSA-2426168Reactome: R-HSA-3371599Reactome: R-HSA-75105 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Acetyl-Coa Carboxylase 1 antibodyAnti-Acc1 antibodyAnti-Acetyl-Coenzyme A Carboxylase Alpha antibodyAnti-Acc-Alpha antibodyAnti-ACACA antibodyAnti-ACAC antibodyAnti-ACC1 antibodyAnti-ACCA antibody |
Information sourced from Uniprot.org