Anti-Recombinant-PDE2A antibody [RM1C87] (STJA0022883)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Cgmp-Dependent 3 5 Cyclic Phosphodiesterase for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1C87 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | PDE2A |
| Gene ID | 5138 |
| Uniprot ID | PDE2A_HUMAN |
Additional Info
| Function | cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. Plays a role in cell growth and migration. Isoform PDE2A2: Regulates mitochondrial cAMP levels and respiration. Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L. |
| Protein Name | Cgmp-Dependent 3' -5'-Cyclic PhosphodiesteraseCyclic Gmp-Stimulated PhosphodiesteraseCgs-PdeCgspde |
| Database Links | Reactome: R-HSA-418457Reactome: R-HSA-418555 |
| Cellular Localisation | Isoform Pde2a3: Cell MembraneLipid-AnchorIsoform Pde2a2: Mitochondrion MatrixMitochondrion Inner MembraneMitochondrion Outer MembraneIsoform Pde2a1: CytoplasmIsoform 5: Mitochondrion |
| Alternative Antibody Names | Anti-Cgmp-Dependent 3' -5'-Cyclic Phosphodiesterase antibodyAnti-Cyclic Gmp-Stimulated Phosphodiesterase antibodyAnti-Cgs-Pde antibodyAnti-Cgspde antibodyAnti-PDE2A antibody |
Information sourced from Uniprot.org