Anti-Recombinant-PDCD4 antibody [RM2H78] (STJA0025745)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Programmed Cell Death Protein 4 for use in FC, IF, IHC and WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IF/IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2H78 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | PDCD4 |
| Gene ID | 27250 |
| Uniprot ID | PDCD4_HUMAN |
Additional Info
| Post Translational Modifications | Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation. Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens.phosphorylation promotes proteasomal degradation of PDCD4. |
| Function | Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA. |
| Protein Name | Programmed Cell Death Protein 4Neoplastic Transformation Inhibitor ProteinNuclear Antigen H731-LikeProtein 197/15a |
| Database Links | Reactome: R-HSA-8950505 |
| Cellular Localisation | NucleusCytoplasmShuttles Between The Nucleus And CytoplasmPredominantly Nuclear Under Normal Growth ConditionsAnd When Phosphorylated At Ser-457 |
| Alternative Antibody Names | Anti-Programmed Cell Death Protein 4 antibodyAnti-Neoplastic Transformation Inhibitor Protein antibodyAnti-Nuclear Antigen H731-Like antibodyAnti-Protein 197/15a antibodyAnti-PDCD4 antibodyAnti-H731 antibody |
Information sourced from Uniprot.org