Anti-Recombinant-OGA antibody [RM1E63] (STJA0023057)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Protein O-Glcnacase for use in IHC, IP and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1E63 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IHC: 1:100-1:200 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | OGA |
| Gene ID | 10724 |
| Uniprot ID | OGA_HUMAN |
Additional Info
| Post Translational Modifications | Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other.cleavage does not decrease enzyme activity. |
| Function | Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro). Does not bind acetyl-CoA and does not have histone acetyltransferase activity. Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1. |
| Protein Name | Protein O-GlcnacaseOgaBeta-N-AcetylglucosaminidaseBeta-N-AcetylhexosaminidaseBeta-HexosaminidaseMeningioma-Expressed Antigen 5N-Acetyl-Beta-D-GlucosaminidaseN-Acetyl-Beta-GlucosaminidaseNuclear Cytoplasmic O-Glcnacase And AcetyltransferaseNcoat |
| Database Links | |
| Cellular Localisation | Isoform 3: NucleusIsoform 1: Cytoplasm |
| Alternative Antibody Names | Anti-Protein O-Glcnacase antibodyAnti-Oga antibodyAnti-Beta-N-Acetylglucosaminidase antibodyAnti-Beta-N-Acetylhexosaminidase antibodyAnti-Beta-Hexosaminidase antibodyAnti-Meningioma-Expressed Antigen 5 antibodyAnti-N-Acetyl-Beta-D-Glucosaminidase antibodyAnti-N-Acetyl-Beta-Glucosaminidase antibodyAnti-Nuclear Cytoplasmic O-Glcnacase And Acetyltransferase antibodyAnti-Ncoat antibodyAnti-OGA antibodyAnti-HEXC antibodyAnti-KIAA0679 antibodyAnti-MEA5 antibodyAnti-MGEA5 antibody |
Information sourced from Uniprot.org