Anti-Recombinant-NUMB antibody [RM1X63] (STJA0024740)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Protein Numb Homolog for use in IHC, IP and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1X63 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IHC: 1:50-1:100 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | NUMB |
| Gene ID | 8650 |
| Uniprot ID | NUMB_HUMAN |
Additional Info
| Function | Regulates clathrin-mediated receptor endocytosis. Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. |
| Protein Name | Protein Numb HomologH-NumbProtein S171 |
| Database Links | Reactome: R-HSA-2122948Reactome: R-HSA-437239Reactome: R-HSA-5610780Reactome: R-HSA-5632684Reactome: R-HSA-9725554 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideEndosome MembraneLocalizes To Perinuclear Endosomes In An Aak1-Dependent Manner |
| Alternative Antibody Names | Anti-Protein Numb Homolog antibodyAnti-H-Numb antibodyAnti-Protein S171 antibodyAnti-NUMB antibodyAnti-C14orf41 antibody |
Information sourced from Uniprot.org