Anti-Recombinant-NME2 antibody [RM1S03] (STJA0024185)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Nucleoside Diphosphate Kinase B for use in IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1S03 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IHC: 1:50-1:100 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | NME2 |
| Gene ID | 4831 |
| Uniprot ID | NDKB_HUMAN |
Additional Info
| Function | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene.binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not. Exhibits histidine protein kinase activity. |
| Protein Name | Nucleoside Diphosphate Kinase BNdk BNdp Kinase BC-Myc Purine-Binding Transcription Factor PufHistidine Protein Kinase NdkbNm23-H2 |
| Database Links | Reactome: R-HSA-499943Reactome: R-HSA-6798695Reactome: R-HSA-9748787Reactome: R-HSA-9755088 |
| Cellular Localisation | CytoplasmCell ProjectionLamellipodiumRuffleColocalizes With Itgb1 And Itgb1bp1 At The Edge Or Peripheral Ruffles And Lamellipodia During The Early Stages Of Cell Spreading On Fibronectin Or Collagen But Not On Vitronectin Or Laminin SubstratesIsoform 1: CytoplasmPerinuclear RegionNucleusIsoform 3: Cytoplasm |
| Alternative Antibody Names | Anti-Nucleoside Diphosphate Kinase B antibodyAnti-Ndk B antibodyAnti-Ndp Kinase B antibodyAnti-C-Myc Purine-Binding Transcription Factor Puf antibodyAnti-Histidine Protein Kinase Ndkb antibodyAnti-Nm23-H2 antibodyAnti-NME2 antibodyAnti-NM23B antibody |
Information sourced from Uniprot.org