Anti-Recombinant-NME1 antibody [RM1P81] (STJA0023966)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Nucleoside Diphosphate Kinase A for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1P81 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | WB: 1:500-1:1000 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | NME1 |
| Gene ID | 4830 |
| Uniprot ID | NDKA_HUMAN |
Additional Info
| Function | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. |
| Protein Name | Nucleoside Diphosphate Kinase ANdk ANdp Kinase AGranzyme A-Activated DnaseGaadMetastasis Inhibition Factor Nm23Nm23-H1Tumor Metastatic Process-Associated Protein |
| Database Links | Reactome: R-HSA-499943Reactome: R-HSA-9748787Reactome: R-HSA-9755088 |
| Cellular Localisation | CytoplasmNucleusCell-Cycle Dependent Nuclear Localization Which Can Be Induced By Interaction With Epstein-Barr Viral Proteins Or By Degradation Of The Set Complex By Gzma |
| Alternative Antibody Names | Anti-Nucleoside Diphosphate Kinase A antibodyAnti-Ndk A antibodyAnti-Ndp Kinase A antibodyAnti-Granzyme A-Activated Dnase antibodyAnti-Gaad antibodyAnti-Metastasis Inhibition Factor Nm23 antibodyAnti-Nm23-H1 antibodyAnti-Tumor Metastatic Process-Associated Protein antibodyAnti-NME1 antibodyAnti-NDPKA antibodyAnti-NM23 antibody |
Information sourced from Uniprot.org