Anti-Recombinant-NHERF-3/PDZK1 antibody [RM2N92] (STJA0026254)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Na (+/H (+ Exchange Regulatory Cofactor Nhe-Rf3 for use in IP and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IP/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2N92 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IP: 1:20-1:50, WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | PDZK1 |
| Gene ID | 5174 |
| Uniprot ID | NHRF3_HUMAN |
Additional Info
| Function | A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function. |
| Protein Name | Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf3Nherf-3Cftr-Associated Protein Of 70 KdaNa(+/H(+ Exchanger Regulatory Factor 3Na/Pi Cotransporter C-Terminal-Associated Protein 1Napi-Cap1Pdz Domain-Containing Protein 1Sodium-Hydrogen Exchanger Regulatory Factor 3 |
| Database Links | |
| Cellular Localisation | MembranePeripheral Membrane ProteinCell MembraneAssociated With Peripheral MembranesLocalizes To The Apical Compartment Of Proximal Tubular Cells And To Sinusoidal Liver Membranes |
| Alternative Antibody Names | Anti-Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf3 antibodyAnti-Nherf-3 antibodyAnti-Cftr-Associated Protein Of 70 Kda antibodyAnti-Na(+/H(+ Exchanger Regulatory Factor 3 antibodyAnti-Na/Pi Cotransporter C-Terminal-Associated Protein 1 antibodyAnti-Napi-Cap1 antibodyAnti-Pdz Domain-Containing Protein 1 antibodyAnti-Sodium-Hydrogen Exchanger Regulatory Factor 3 antibodyAnti-PDZK1 antibodyAnti-CAP70 antibodyAnti-NHERF3 antibodyAnti-PDZD1 antibody |
Information sourced from Uniprot.org