Anti-Recombinant-NFKBIB antibody [RM2G49] (STJA0025617)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Nf-Kappa-B Inhibitor Beta for use in IHC, IP and WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2G49 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | NFKBIB |
| Gene ID | 4793 |
| Uniprot ID | IKBB_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylated by RPS6KA1.followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation. |
| Function | Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. |
| Protein Name | Nf-Kappa-B Inhibitor BetaNf-Kappa-BibI-Kappa-B-BetaIkb-BIkb-BetaIkappabbetaThyroid Receptor-Interacting Protein 9Tr-Interacting Protein 9Trip-9 |
| Database Links | Reactome: R-HSA-1169091Reactome: R-HSA-1810476Reactome: R-HSA-445989Reactome: R-HSA-933542 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Nf-Kappa-B Inhibitor Beta antibodyAnti-Nf-Kappa-Bib antibodyAnti-I-Kappa-B-Beta antibodyAnti-Ikb-B antibodyAnti-Ikb-Beta antibodyAnti-Ikappabbeta antibodyAnti-Thyroid Receptor-Interacting Protein 9 antibodyAnti-Tr-Interacting Protein 9 antibodyAnti-Trip-9 antibodyAnti-NFKBIB antibodyAnti-IKBB antibodyAnti-TRIP9 antibody |
Information sourced from Uniprot.org