| Short Description : | Rabbit monoclonal Recombinant-MGMT antibody for use in IHC-P in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC-P |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | ZR434 |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | Affinity purified |
| Dilution Range: | 1:100-200 |
| Formulation: | Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin |
| Storage Instruction: | Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C. |
| Gene Symbol: | MGMT |
| Gene ID: | 4255 |
| Uniprot ID: | MGMT_HUMAN |
| Immunogen: | Purified His-tagged MGMT protein |
| Specificity: | Positive Control: Colon carcinoma |
| Function | Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. |
| Protein Name | Methylated-Dna--Protein-Cysteine Methyltransferase6-O-Methylguanine-Dna MethyltransferaseMgmtO-6-Methylguanine-Dna-Alkyltransferase |
| Database Links | Reactome: R-HSA-5657655 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Methylated-Dna--Protein-Cysteine Methyltransferase antibodyAnti-6-O-Methylguanine-Dna Methyltransferase antibodyAnti-Mgmt antibodyAnti-O-6-Methylguanine-Dna-Alkyltransferase antibodyAnti-MGMT antibody |
Information sourced from Uniprot.org
