Anti-Recombinant-MEN1 antibody [RM1C73] (STJA0022869)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Menin for use in IP and WB in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IP/WB |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1C73 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IP: 1:20 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | MEN1 |
| Gene ID | 4221 |
| Uniprot ID | MEN1_HUMAN |
Additional Info
| Function | Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair. |
| Protein Name | Menin |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-2173796Reactome: R-HSA-3769402Reactome: R-HSA-381426Reactome: R-HSA-5626467Reactome: R-HSA-8957275Reactome: R-HSA-9772755 |
| Cellular Localisation | NucleusConcentrated In Nuclear Body-Like StructuresRelocates To The Nuclear Matrix Upon Gamma Irradiation |
| Alternative Antibody Names | Anti-Menin antibodyAnti-MEN1 antibodyAnti-SCG2 antibody |
Information sourced from Uniprot.org