Anti-Recombinant-LFNG antibody [RM2Q08] (STJA0026368)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Beta-1-3-N-Acetylglucosaminyltransferase Lunatic Fringe for use in IF and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2Q08 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IF: 1:50-1:200, WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | LFNG |
| Gene ID | 3955 |
| Uniprot ID | LFNG_HUMAN |
Additional Info
| Function | Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. Decreases the binding of JAG1 to NOTCH2 but not that of DLL1. Essential mediator of somite segmentation and patterning. |
| Protein Name | Beta-1 -3-N-Acetylglucosaminyltransferase Lunatic FringeO-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase |
| Database Links | Reactome: R-HSA-1912420Reactome: R-HSA-5083630Reactome: R-HSA-9824272Reactome: R-HSA-9831926 |
| Cellular Localisation | Golgi ApparatusGolgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Beta-1 -3-N-Acetylglucosaminyltransferase Lunatic Fringe antibodyAnti-O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase antibodyAnti-LFNG antibody |
Information sourced from Uniprot.org