Anti-Recombinant-KHSRP antibody [RM2Q89] (STJA0026449)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Far Upstream Element-Binding Protein 2 for use in IF, IHC, IP and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2Q89 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IF: 1:50-1:200, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | KHSRP |
| Gene ID | 8570 |
| Uniprot ID | FUBP2_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-193 leads to the unfolding of the unstable KH domain 1, creating a site for 14-3-3 YWHAZ binding, which promotes nuclear localization and impairs the RNA degradation function. |
| Function | Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. |
| Protein Name | Far Upstream Element-Binding Protein 2Fuse-Binding Protein 2Kh Type-Splicing Regulatory ProteinKsrpP75 |
| Database Links | Reactome: R-HSA-380994Reactome: R-HSA-450604 |
| Cellular Localisation | NucleusCytoplasmA Small Proportion Is Also Found In The Cytoplasm Of Neuronal Cell Bodies And Dendrites |
| Alternative Antibody Names | Anti-Far Upstream Element-Binding Protein 2 antibodyAnti-Fuse-Binding Protein 2 antibodyAnti-Kh Type-Splicing Regulatory Protein antibodyAnti-Ksrp antibodyAnti-P75 antibodyAnti-KHSRP antibodyAnti-FUBP2 antibody |
Information sourced from Uniprot.org