Anti-Recombinant-KCTD21 antibody [RM2H72] (STJA0025739)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Btb/Poz Domain-Containing Protein Kctd21 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2H72 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | WB: 1:500-1:1000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | KCTD21 |
| Gene ID | 283219 |
| Uniprot ID | KCD21_HUMAN |
Additional Info
| Function | Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1.the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). |
| Protein Name | Btb/Poz Domain-Containing Protein Kctd21Kcash2 ProteinPotassium Channel Tetramerization Domain-Containing Protein 21 |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Btb/Poz Domain-Containing Protein Kctd21 antibodyAnti-Kcash2 Protein antibodyAnti-Potassium Channel Tetramerization Domain-Containing Protein 21 antibodyAnti-KCTD21 antibody |
Information sourced from Uniprot.org