Anti-Recombinant-JUP antibody [RM1P55] (STJA0023940)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Junction Plakoglobin for use in IF, IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1P55 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IF: 1:50-1:200 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | JUP |
| Gene ID | 3728 |
| Uniprot ID | PLAK_HUMAN |
Additional Info
| Post Translational Modifications | May be phosphorylated by FER. |
| Function | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. |
| Protein Name | Junction PlakoglobinCatenin GammaDesmoplakin IiiDesmoplakin-3 |
| Database Links | Reactome: R-HSA-418990Reactome: R-HSA-5218920Reactome: R-HSA-6798695Reactome: R-HSA-6805567Reactome: R-HSA-6809371Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013406Reactome: R-HSA-9013407Reactome: R-HSA-9013409Reactome: R-HSA-9762292Reactome: R-HSA-9764302Reactome: R-HSA-9833576 |
| Cellular Localisation | Cell JunctionAdherens JunctionDesmosomeCytoplasmCytoskeletonCell MembranePeripheral Membrane ProteinNucleusCytoplasmic In A Soluble And Membrane-Associated FormColocalizes With Dsg4 At Desmosomes |
| Alternative Antibody Names | Anti-Junction Plakoglobin antibodyAnti-Catenin Gamma antibodyAnti-Desmoplakin Iii antibodyAnti-Desmoplakin-3 antibodyAnti-JUP antibodyAnti-CTNNG antibodyAnti-DP3 antibody |
Information sourced from Uniprot.org