Anti-Recombinant-INPP4B antibody [RM1D72] (STJA0022967)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Inositol Polyphosphate 4-Phosphatase Type Ii for use in WB in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1D72 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | WB: 1:500-1:1000 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | INPP4B |
| Gene ID | 8821 |
| Uniprot ID | INP4B_HUMAN |
Additional Info
| Function | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate. Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles. The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. |
| Protein Name | Inositol Polyphosphate 4-Phosphatase Type IiType Ii Inositol 3 -4-Bisphosphate 4-Phosphatase |
| Database Links | Reactome: R-HSA-1660499Reactome: R-HSA-1660516Reactome: R-HSA-1855183 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Inositol Polyphosphate 4-Phosphatase Type Ii antibodyAnti-Type Ii Inositol 3 -4-Bisphosphate 4-Phosphatase antibodyAnti-INPP4B antibody |
Information sourced from Uniprot.org