Anti-Recombinant-IGFBP1 antibody [RM1L83] (STJA0023671)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Insulin-Like Growth Factor-Binding Protein 1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1L83 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | IGFBP1 |
| Gene ID | 3484 |
| Uniprot ID | IBP1_HUMAN |
Additional Info
| Function | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner. Also plays a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif. Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway. Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation. |
| Protein Name | Insulin-Like Growth Factor-Binding Protein 1Ibp-1Igf-Binding Protein 1Igfbp-1Placental Protein 12Pp12 |
| Database Links | Reactome: R-HSA-380994Reactome: R-HSA-381426Reactome: R-HSA-8957275Reactome: R-HSA-9615017 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Insulin-Like Growth Factor-Binding Protein 1 antibodyAnti-Ibp-1 antibodyAnti-Igf-Binding Protein 1 antibodyAnti-Igfbp-1 antibodyAnti-Placental Protein 12 antibodyAnti-Pp12 antibodyAnti-IGFBP1 antibodyAnti-IBP1 antibody |
Information sourced from Uniprot.org