Anti-Recombinant-IGF2BP2 antibody [RM2L31] (STJA0025995)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Insulin-Like Growth Factor 2 Mrna-Binding Protein 2 for use in IF, IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2L31 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | IGF2BP2 |
| Gene ID | 10644 |
| Uniprot ID | IF2B2_HUMAN |
Additional Info
| Function | RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD. |
| Protein Name | Insulin-Like Growth Factor 2 Mrna-Binding Protein 2Igf2 Mrna-Binding Protein 2Imp-2Hepatocellular Carcinoma Autoantigen P62Igf-Ii Mrna-Binding Protein 2Vickz Family Member 2 |
| Database Links | Reactome: R-HSA-428359 |
| Cellular Localisation | NucleusCytoplasmP-BodyStress GranuleLocalized In Cytoplasmic Mrnp Granules Containing Untranslated MrnasLocalizes At The Connecting Piece And The Tail Of The SpermatozoaIn Response To Cellular StressSuch As Oxidative StressRecruited To Stress Granules |
| Alternative Antibody Names | Anti-Insulin-Like Growth Factor 2 Mrna-Binding Protein 2 antibodyAnti-Igf2 Mrna-Binding Protein 2 antibodyAnti-Imp-2 antibodyAnti-Hepatocellular Carcinoma Autoantigen P62 antibodyAnti-Igf-Ii Mrna-Binding Protein 2 antibodyAnti-Vickz Family Member 2 antibodyAnti-IGF2BP2 antibodyAnti-IMP2 antibodyAnti-VICKZ2 antibody |
Information sourced from Uniprot.org