Anti-Recombinant-HSPH1 antibody [RM2P17] (STJA0026278)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Heat Shock Protein 105 Kda for use in IF, IHC, IP and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2P17 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IF: 1:50-1:200, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | HSPH1 |
| Gene ID | 10808 |
| Uniprot ID | HS105_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity. |
| Function | Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. |
| Protein Name | Heat Shock Protein 105 KdaAntigen Ny-Co-25Heat Shock 110 Kda ProteinHeat Shock Protein Family H Member 1 |
| Database Links | Reactome: R-HSA-3000484Reactome: R-HSA-3371453 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Heat Shock Protein 105 Kda antibodyAnti-Antigen Ny-Co-25 antibodyAnti-Heat Shock 110 Kda Protein antibodyAnti-Heat Shock Protein Family H Member 1 antibodyAnti-HSPH1 antibodyAnti-HSP105 antibodyAnti-HSP110 antibodyAnti-KIAA0201 antibody |
Information sourced from Uniprot.org