Anti-Recombinant-HMGCL antibody [RM1V30] (STJA0024509)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Hydroxymethylglutaryl-Coa Lyase-Mitochondrial for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1V30 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | WB: 1:500-1:1000 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | HMGCL |
| Gene ID | 3155 |
| Uniprot ID | HMGCL_HUMAN |
Additional Info
| Function | Mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. |
| Protein Name | Hydroxymethylglutaryl-Coa Lyase - MitochondrialHlHmg-Coa Lyase3-Hydroxy-3-Methylglutarate-Coa Lyase |
| Database Links | Reactome: R-HSA-77111Reactome: R-HSA-9033241 |
| Cellular Localisation | Mitochondrion MatrixPeroxisomeUnprocessed Form Is Peroxisomal |
| Alternative Antibody Names | Anti-Hydroxymethylglutaryl-Coa Lyase - Mitochondrial antibodyAnti-Hl antibodyAnti-Hmg-Coa Lyase antibodyAnti-3-Hydroxy-3-Methylglutarate-Coa Lyase antibodyAnti-HMGCL antibody |
Information sourced from Uniprot.org