Anti-Recombinant-HMBS antibody [RM1L61] (STJA0023649)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Porphobilinogen Deaminase for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1L61 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | WB: 1:1000-1:2000 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | HMBS |
| Gene ID | 3145 |
| Uniprot ID | HEM3_HUMAN |
Additional Info
| Function | As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen. Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact. |
| Protein Name | Porphobilinogen DeaminasePbg-DHydroxymethylbilane SynthaseHmbsPre-Uroporphyrinogen Synthase |
| Database Links | Reactome: R-HSA-189451 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Porphobilinogen Deaminase antibodyAnti-Pbg-D antibodyAnti-Hydroxymethylbilane Synthase antibodyAnti-Hmbs antibodyAnti-Pre-Uroporphyrinogen Synthase antibodyAnti-HMBS antibodyAnti-PBGD antibodyAnti-UPS antibody |
Information sourced from Uniprot.org