Anti-Recombinant-GCSAM antibody [RM2Q93] (STJA0026453)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Germinal Center-Associated Signaling And Motility Protein for use in FC, IF and IHC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IF/IHC |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2Q93 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | GCSAM |
| Gene ID | 257144 |
| Uniprot ID | GCSAM_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylation on tyrosine residues can be induced by IL6. Phosphorylation is mediated by LYN. Targeted by the ubiquitin E3 ligase subunit FBXO10 to mediate its ubiquitination and degradation. |
| Function | Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. |
| Protein Name | Germinal Center-Associated Signaling And Motility ProteinGerminal Center B-Cell-Expressed Transcript 2 ProteinGerminal Center-Associated Lymphoma ProteinHgal |
| Database Links | |
| Cellular Localisation | CytoplasmCell MembraneIt Relocalizes From The Cytoplasm To Podosome-Like Structures Upon Cell Treatment With Il6 |
| Alternative Antibody Names | Anti-Germinal Center-Associated Signaling And Motility Protein antibodyAnti-Germinal Center B-Cell-Expressed Transcript 2 Protein antibodyAnti-Germinal Center-Associated Lymphoma Protein antibodyAnti-Hgal antibodyAnti-GCSAM antibodyAnti-GAL antibodyAnti-GCET2 antibody |
Information sourced from Uniprot.org